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Journal of Pediatric Oncology Nursing
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Chemotherapy-Related Fatigue in Childhood Cancer: Correlates, Consequences, and Coping Strategies

Stan F. Whitsett, PhD

Department of Pediatrics (MCHK-PED), Tripler Army Medical Center, Honolulu, Hawaii, stan.whitsett{at}us.army.mil

Maria Gudmundsdottir, PhD, RN

Department of Family Health Care Nursing, University of California, San Francisco

Betty Davies, PhD, RN, FAAN

Acute Care Pediatric Nurse Practitioner Program, Department of Family Health Care Nursing, University of California, San Francisco

Patricia McCarthy, MSc A, RN

Pediatric Oncology Department, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada

Debra Friedman, MD

Survivorship Program of the Fred Hutchinson Cancer Research Center

The aim of this research is to examine the experience and impact of chemotherapy-related fatigue in recently diagnosed pediatric oncology patients. A repeated-measures, within-subjects, mixed (quantitative plus qualitative) design was used to prospectively assess fatigue during early chemotherapy cycles and to compare fatigue to depressive symptoms. Parental interviews collected concurrently were analyzed for descriptions of the child's fatigue and mood states and for strategies to cope with fatigue. Results indicated a significant correlation between fatigue and depression, but qualitative analyses suggested that the 2 phenomena may be unique and distinguishable. Qualitative analyses of parent interviews also identified specific strategies that were frequently used in response to high levels of fatigue. The findings illustrate the significant impact of chemotherapy-related fatigue in children being treated for cancer. The study also provides guidance for the assessment of fatigue and related symptoms and identifies specific strategies for coping with fatigue.

Key Words: Key words: fatigue • pediatric oncology • depression • symptoms • mixed methodology

This version was published on April 1, 2008

Journal of Pediatric Oncology Nursing, Vol. 25, No. 2, 86-96 (2008)
DOI: 10.1177/1043454208315546
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