This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Riddel, J. P. Articles by Lillicrap, D. P. Search for Related Content PubMed PubMed Citation Articles by Riddel, J. P., Jr. Articles by Lillicrap, D. P. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                   What's this?

Theories of Blood Coagulation

Division of Hematology at Children's Hospital and Research Center Oakland, Oakland, California, jriddel{at}mail.cho.org

Bradley E. Aouizerat, PhD

Department of Physiological Nursing & Institute for Human Genetics at the University of California, San Francisco

Christine Miaskowski, RN, PhD

Department of Physiological Nursing at the University of California, San Francisco

David P. Lillicrap, MD, FRCPC

Department of Pathology & Molecular Medicine at Queen's University, Kingston, Ontario, Canada

Although the concept of the coagulation cascade represented a significant advance in the understanding of coagulation and served for many years as a useful model, more recent clinical and experimental observations demonstrate that the cascade/waterfall hypothesis does not fully and completely reflect the events of hemostasis in vivo. The goal of this article is to review the evolution of the theories of coagulation and their proposed models to serve as a tool when reviewing the research and practice literature that was published in the context of these different theories over time.

Key Words: coagulation • coagulation cascade • cell-based theory of coagulation • bleeding disorders

Journal of Pediatric Oncology Nursing, Vol. 24, No. 3, 123-131 (2007)
DOI: 10.1177/1043454206298693


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				G. Romney and M. Glick An Updated Concept of Coagulation With Clinical Implications J Am Dent Assoc, May 1, 2009; 140(5): 567 - 574. [Abstract] [Full Text] [PDF]