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DOI: 10.1177/1043454205275407 © 2005 Association of Pediatric Hematology/Oncology Nurses Factor V Leiden and Its Effect on Children With Cardiac PathologyDepartment of Cardiology, Childrens Hospital, 300 Longwood Avenue, Boston, MA 02115Jean.Connor{at}cardio.chboston.org Factor V Leiden thrombophilia, formed by a genetic mutation, slows the bodys anticoagulation response to clot formation. First described in 1994, factor V Leiden mutation has been identified as a contributing risk factor for venous thromboembolism. Although venous thromboembolism is considered rare in the pediatric population, Factor V Leiden has implications for certain at-risk pediatric patients.
Key Words: Factor V Leiden children with congenital heart disease genetic screening pediatric risk factors pediatrics prevalence venous thrombosis
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