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Journal of Pediatric Oncology Nursing
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Neuropathic Pain in Children With Cancer

Eufemia Jacob, PhD, RN

Baylor College of Medicine, Texas Children’s Cancer Center, Houston, exjacob{at}texaschildrenshospital.org

Different mechanisms of cancer pain may involve somatic, visceral, and neural tissues. Pain that involves the neural tissues is classified as neuropathic pain and is less responsive to analgesics than pain that involves somatic and visceral tissues. Because young children are unable to describe the quality of pain, presence of neuropathic pain with cancer may be unrecognized and undetected. The purpose of this article is to explain the nature of neuropathic pain, to review the literature related to children with cancer that suggests the presence of neuropathic pain, to outline assessment strategies that may lead to appropriate detection of neuropathic pain in children, and to discuss challenges in the management of neuropathic pain. Future research is needed to characterize the intensity, location, quality, and duration of neuropathic pain in children. In addition, research that would determine the efficacy of opioids, nonsteroidal anti-inflammatory drugs, and adjuvant analgesics (antidepressants, anticonvulsants) is needed to increase the nurses’ ability to assess and manage neuropathic pain in children with cancer.

Key Words: neuropathic pain • cancer pain • pain assessment • pain management

Journal of Pediatric Oncology Nursing, Vol. 21, No. 6, 350-357 (2004)
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This article has been cited by other articles:


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 Journal of Pediatric Oncology NursingHome page
M. Conway, N. White, C. St. Jean, W. T. Zempsky, and K. Steven
Use of Continuous Intravenous Ketamine for End-Stage Cancer Pain in Children
Journal of Pediatric Oncology Nursing, March 1, 2009; 26(2): 100 - 106.
[Abstract] [PDF]

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 Journal of Pediatric Oncology NursingHome page
E. Jacob, J. Hesselgrave, G. Sambuco, and M. Hockenberry
Variations in Pain, Sleep, and Activity During Hospitalization in Children With Cancer
Journal of Pediatric Oncology Nursing, August 1, 2007; 24(4): 208 - 219.
[Abstract] [PDF]


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