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Doxorubicin-Induced Cardiomyopathy

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Doxorubicin (Adriamycin; Adria Laboratories, Columbus, OH) is one of the most effective chemotherapeutic agents used in the management of pediatric neoplastic disorders during the past 20 years. However, its use has been limited by well-characterized, dose-related cardiac toxicity. Recently, cardiac dysfunction has been noted in pediatric patients who had received doxorubicin years before. This article summarizes current information regarding the pathophysiology and risk factors associated with cardiotoxicity and reviews detection methods and treatments of this condition.

Journal of Pediatric Oncology Nursing, Vol. 11, No. 4, 152-160 (1994)
DOI: 10.1177/104345429401100406


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				M. A. Hollinger and S. N. Giri In Vitro Uptake and Subcellular Distribution of the Cardiotoxin [3H]Adriamycin in Mouse Ventricle Slices International Journal of Toxicology, October 1, 1996; 15(5): 408 - 415. [Abstract] [PDF]